Abstract
The absorption rate of thiamine by excised intestinal loops of diabetic rats was compared with that of normal rats. There was no significant difference between the amount of thiamine absorbed by the intestine of normal rats and that of insulin administered rats. On the other hand, the absorption by the intestine of totally pancreatectomized or alloxan diabetic rats was coosiderably less than in the case of the normal rats, and esterification of the absorbed thiamine was not seen at all in the former. When ATP was added into the intestinal lumen with thiamine, the absorption increased markedly in alloxan diabetic rats and the absorbed thiamine was phosphorylated to some extent, while in normal rats such effect of ATP on the absorption of thiamine was very slight.
