抄録
Diabetes mellitus (DM), which develops many secondary complications, is mainly classified as either insulin-dependent type 1 or non-insulin-dependent type 2. Several types of insulin preparations for type 1 DM and those of synthetic pharmaceuticals have been clinically used; however, those have some problems such as physical and mental pain due to daily insulin injections and defects such as side effects due to toxicity, respectively. To develop new types of pharmaceuticals, metallocomplexes containing vanadium and zinc ions were prepared to treat not only both types of experimental DM but also metabolic syndromes in animals such as obese and hypertension. In this article, the current state of development in our research group on insulin-mimetic vanadium and zinc complexes with different coordination environments is reviewed.
