腸内細菌のパントテン酸前駆体の投与がパントテン酸欠乏幼若ラットの成長とパントテン酸の尿中排泄量におよぼす影響

抄録

Pantothenic acid is very unstable under acid or alkaline conditions to be hydrolyzed to pantolactone and β-alanine. There is no information of the pantothenate deficiency which might be caused by hydrolysis with gastric acid. It may be possible that pantothenate is synthesized again from pantolactone and β-alanine by enterobacteria. Accordinngly when pantolactone and β-alanine was administered to pantothenate-deficient infant rats, the growth and pantotheate content in liver and urine were compared with normal rats. Consequently pantolactone and β-alanine has not supported the growth similar to pantothenate-deficiency.