ビタミンCとグルタチオンS-トランスフェラーゼの遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンC-)

抄録

There are many gene polymorphisms for glutathione S-transferases (GSTs). The relationship between vitamin C (VC) and gene polymorphisms for GSTs was first explored in 2001 in a study of middle-aged men in Slovakia which found that GSTM1-null genotype was related with increasing circulating VC levels. This was also observed in a more recent study in a US cohort, where individuals with the highest serum VC levels were more likely to be GSTM1-null than to have a functional copy of GSTM1. However, this relationship between blood VC levels and the presence of GSTM1 has not been universally observed. Two studies, one in a Chinese cohort and another with nonsmoking adults in Canada, showed no differences in blood VC status associated with GSTM1 genotype. In a study of factory workers in Slovakia, an overall decline in plasma VC levels was found to be associated with GSTM1-null genotype. Thus, it appears that there are interactions between blood VC levels and gene polymorphisms for GSTs, but overall conclusions are difficult to reach. Therefore, further studies are needed to clarify the relationship between blood VC levels and gene polymorphisms for GSTs.