抄録
The crystal structure of epalrestat dimethanol-solvate (C15H13NO3S2·2CH3OH) was determined by X-ray crystallography. The crystal is a pseudopolymorphic form of the previously reported monomethanol solvate. The compound crystallized in a monoclinic system, and was characterized as follows: P1, a = 7.8868(2)Å, b = 8.1577(3)Å, c = 16.1069(5)Å, α = 85.5626(19)°, β = 77.790(2)°, γ = 67.5381(18)°, Z = 2, V = 936.00(5)Å3. The pattern of the hydrogen bonds is designated by the graph-set R66(16), composed of two epalrestat and four methanol molecules. The planarity of the epalrestat molecules is lower than that of all other reported polymorphic forms of epalrestat.
