YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Regular Articles
Reaction of Pyridinium Salts with Active Methylene Compounds
Reiko FUJITA, Masato HOSHINO, Yasuhiro NISHIUCHI, Hiroshi TOMISAWA
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Keywords: 1-methyl-2-methylthio-4-phenylpyridinium salt, dimethyl malonate, sodium hydride, 1-methyl-2-methylthio-5-phenylpyridinium iodide, 1-methyl-2-methylthio-6-phenylpyridinium iodide, malononitrile
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2006 Volume 126 Issue 2 Pages 109-116

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Abstract
  The carbon-carbon bond-forming reactions of 1-methyl-2-methylthiophenylpyridinium iodides with active methylene compounds (such as dimethyl malonate, malononitrile) using NaH as a base gave the 2-substituted methylene-1,2-dihydropyridine derivatives.
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© 2006 by the PHARMACEUTICAL SOCIETY OF JAPAN
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