ロジウム触媒を用いる有機フッ素化合物の新反応の開発

抄録

  Novel fluoroalkylated products where a CF₂COOEt group was introduced at the α-position of α,β-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF₂COOEt and α,β-unsaturated ketones with Et₂Zn in the presence of RhCl(PPh₃)₃ depending on the solvents. Furthermore, the novel α-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (R_f-X) instead of BrCF₂COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-β-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO₄•7H₂O, selectively.