Preparation of N-Succinyl-chitosan and Their Physical-Chemical Properties as a Novel Excipient

抄録

  The aim of this work is to prepare N-succinyl-chitosan (Suc-Chi) and measure physical-chemical properties for Suc-Chi as excipients. Suc-Chi were prepared via ring-opening reactions with succinic anhydride in Dimethyl Sulfoxide system. The physical-chemical properties of Suc-Chi, such as the degree of substitution (DS), solubility, isoelectric point (pI), glass transition temperature (Tg), partition coefficient (P_app) and zata potential were detected respectively in order to evaluate their possibility as drug carriers. We obtained Suc-Chi DAC-90 (DS=0.33) and the data of physical-chemical properties for the product. The knowledges of physical-chemical properties for Suc-Chi are valuable for basic or applied purposes in biomedical and pharmaceutical sciences stabilization.