YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
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Antinociceptive and Anti-inflammatory Properties of Corchorus capsularis Leaves Chloroform Extract in Experimental Animal Models
Zainul Amiruddin ZAKARIAMohd. Roslan SULAIMANHanan Kumar GOPALANZuleen Delina Fasya ABDUL GHANIRaden Nur Suraya RADEN MOHD. NORAbdul Manan MAT JAISFatimah Corazon ABDULLAH
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2007 Volume 127 Issue 2 Pages 359-365

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Abstract

  The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by in vacuo evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200 mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p<0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain.

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© 2007 by the PHARMACEUTICAL SOCIETY OF JAPAN
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