YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Symposium Reviews
Structural and Functional Properties of the C-terminal Region of Mitochondrial ADP/ATP Carrier
Yasuo SHINOHARAMitsuru HASHIMOTOYoshitaka KIHIRAKazuto OHKURAEiji MAJIMAHiroshi TERADA
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JOURNAL FREE ACCESS

2010 Volume 130 Issue 2 Pages 199-204

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Abstract
  Mitochondrial ADP/ATP carrier (AAC) is a protein catalyzing the transport of adenine nucleotides across inner mitochondrial membrane. In this review article, we first briefly introduce structural and functional properties of this protein. Next, we describe the results of our recent studies on the difference in the C-terminal region between yeast type 2 AAC isoform and bovine type 1 AAC isoform. Furthermore, based on the reactivities of cysteine residues that replaced amino acids in the sixth transmembrane segment, the probable structural features of the C-terminal region of this carrier are discussed.
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© 2010 by the PHARMACEUTICAL SOCIETY OF JAPAN
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