J-STAGE トップ  >  資料トップ  > 書誌事項

YAKUGAKU ZASSHI
Vol. 133 (2013) No. 12 p. 1297-1306

記事言語:

http://doi.org/10.1248/yakushi.13-00222-5

誌上シンポジウム

  High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve the efficient cell-killing effect of boron neutron capture therapy (BNCT) that relies on the nuclear reaction of two essentially nontoxic species, boron-10 (10B) and thermal neutrons in boron-loaded tissues. Recent development of boron cluster lipids and their liposomal boron delivery system (BDS) are summarized in this article. Boron compounds that have no affinity to tumor can potentially be delivered to tumor tissues by liposomes, therefore, liposomal BDS would be one of the most attractive approaches for efficient BNCT of various cancers. There are two approaches for BDS: encapsulation of boron compounds into liposomes and incorporation of boron-conjugated lipids into the liposomal bilayer. The combination of both approaches has a potential for reduction of the total dose of liposomes without reducing the efficacy of BNCT.

Copyright © 2013 by the PHARMACEUTICAL SOCIETY OF JAPAN

記事ツール

この記事を共有