受賞総説
ニトロキシル型酸化触媒によるp-メトキシベンジル基の脱保護
2021 年 141 巻 10 号 p. 1147-1154
詳細
2021 年 141 巻 10 号 p. 1147-1154
The oxidation of p-methoxybenzyl (PMB) ethers was achieved using a nitroxyl radical catalyst 1, which contains electron-withdrawing ester groups adjacent to the nitroxyl group. The oxidative deprotection of the PMB moieties on the hydroxy groups was observed upon treatment of 1 with one equivalent of the co-oxidant phenyl iodonium bis(trifluoroacetate) (PIFA). This system showed an excellent chemoselectivity profile for the deprotection of PMB ethers from a broad range of functional groups including diverse oxidation-sensitive moieties. The corresponding carbonyl compounds were obtained by treating the PMB-protected alcohols with 1 and an excess amount of PIFA.
