Pharmacological effect of crude extracts CS-2, -3, -5 and-6, obtained from the chinese crude drug"Shoma"(the rhizome of Cimicifuga simplex WORMSK.) was examined in small animals. CS 2 prolonged significantly the sleeping time induced by thiopental and inhibited the convulsion induced by strychnine in mice. CS 3 also had sedative and anticonvulsive effects, but toxicity of CS 3 may be involved in these effects. CS 5 was highly effective in the suppressing contraction induced by norepinephrine in the isolated guinea pig vas deferens and relaxation induced by isoproterenol against contraction induced by acetylcholine in the isolated rat anorectum. Antagonistic effect of CS 6 was observed against contraction induced by serotonin in the isolated guinea pig ileum. Any remarkable effects of CS 5 and CS 6 were observed in the isolated guinea pig tracheal strips and rat uterus.
