Anti-tumor Activities of Some Heterocyclic and Nitrogen-containing Compounds

Abstract

Ten derivatives of isothiourea including 8 new compounds were synthesized and screened for the anti-tumor activity. Twenty nine derivatives of azine, 27 thiourea derivatives, 6 thiazole derivatives, 20 triazoline derivatives and 7 guanidine derivatives were also synthesized and screened for the anti-tumor activity. The anti-tumor activity was assayed by the use of ascitic or solid type of Ehrlich carcinoma. Among them, N-phenyl-S-benzylthioisothiourea·HCl, S-furfurylthioisothiourea·HCl, N-phenyl-S-furfurylthioisothiourea·HCl, 4, 4'-diacetylaminobenzalazine and 2, 3-dihydro-4-methyl-2-(2'-pyridylmethylenehydrazono)thiazole·2HCl were effective against the solid type of Ehrlich carcinoma.