抄録
The biological fate of phenylisopropyl-p-phenylenediamine (PIPD) in the rabbit was examined by GLC and GC-MS methods. It was found that a major metabolite of this compound in the urine was PIPD N-glucuronide, and that the amount of this glucuronide excreted in the urine within 24 hours was 4 times higher than that of the unchanged form. Both PIPD and PIPD N-glucuronide were excreted in the bile more rapidly than in the urine. PIPD was rapidly eliminated from the plasma following intravenous administration, and 25% of the dose accumulated in the liver within 5 hours, of which nearly 70% was PIPD N-glucuronide. In contrast, it was found that the plasma level of PIPD was extremely low following intraduodenal administration, and that 22% of the dose accumulated in the liver within 2 hours. It was suggested that PIPD accumulated rapidly and in large amounts in the liver and was excreted slowly in the urine and in the bile.
