The anti-inflammatory actions of water extracts of snake's moulted skin were investigated to determine profile. The extract was found to have anti-edematous action on carrageenin edema, mustard edema and inhibitory action against leucocyte emigration. However, the extract showed somewhat weaker inhibitory action against increased vascular permeability. In in vitro tests, the extract showed marked inhibitory action on heat-induced hemolysis of rat erythrocytes.