Synthesis of 6-and 7-Substituted 3-Aminoisocarbostyril Derivatives. II. Synthesis of 3-Alkylamino-and 3-Arylamino-isocarbostyril Derivatives

Abstract

3-Alkylamino- and 3-arylamino-isocarbostyril derivatives were synthesized in order to investigate their fluorescent properties. Reactions of (2-cyanomethyl) benzoic acid derivatives (Ia-Ie) with primary amines (cyclohexylamine, benzylamine, and aniline) in chlorobenzene gave the corresponding 3-substituted aminoisocarbostyrils (IIa-IIo) having methoxy or chloro groups at the 6- and/or 7-positions. 3-Alkylaminoisocarbostyrils (IIa-IIc, IIf-IIh, and Va-Vf) were also given by reactions of methyl 2-(2'-ethoxy-2'-iminoethyl) benzoates (IVa-IVc) with alkylamines (methylamine, dimethylamine, cyclohexylamine, and benzylamine) in aqueous solution.