YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Pharmacological Studies of Sodium Alginate. III. Acceleration of Fibrin Formation by Sodium Alginate
KOJI DAIGO, MANABU YAMAJI, CHIAKI YAMADA, YUTAKA WADA, SEIJI OKUDA, MASAYUKI OKADA, TAKASHI MIYAZATO
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Keywords: sodium alginate, fibrinogen, fibrin, thrombin, steric exclusion, fibrin clotting time, fibrin monomer, fibrin polymerisation
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1981 Volume 101 Issue 5 Pages 464-469

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Abstract
The solubility of fibrinogen, fibrin clotting time from fibrinogen and polymerisation of fibrin monomer in the presence of sodium alginate were examined. Sodium alginate precipitated fibrinogen, shortened fibrin clotting time and increased fibrin polymerisation rates. These effects increased with an increase in the molecular weight and concentration of sodium alginate.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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