アベチン酸誘導体(N-(2,6-Dimethylphenyl)-Δ⁸-dihydroabietamide)の結晶形

抄録

By use of X-ray diffractometry, thermal analysis and infrared spectroscopy, the crystal forms of N-(2, 6-dimethylphenyl)-Δ⁸-dihydroabietamide were investigated. Two polymorphic forms (form I and II), two solvates (cyclohexane and CCl₄), and an amorphous form were identified. Heating of form II induced a solid transformation to form I. The transition of form I and II to the amorphous form was observed by grinding. Each solvate contained 9.0% cyclohexane and 16.0% CCl₄ respectively, i.e., drug : solvent=2 : 1. The activation energy of the desolvation was determined from TG curves by using Ozawa's method, and calculated as 72.2 kcal/mol for the cyclohexar solvente, and 35.5 kcal/mol for the CCl₄ solvate.