Dissolution of Solid Drugs. II. Dissolution of Polydisperse Powders

Abstract

The equations were derived for the dissolution of polydisperse powders under sink and nonsink conditions. These were applied to hypothetical powders of log-normally and rosin-rammlerly distributed powders, and practical powders of alkylparabens. To study the dissolution rates of the powders influenced by particle distribution, nonsink condition, solubility and crystal shape, these phenomena were simulated.