肺炎球菌細胞壁中に存在する, リゾチーム消化抵抗性因子

抄録

Streptococcus pneumoniae cell is known to resist to lysozyme digestion. The resistant factor was examined by using cell and solubilized cell wall components (AS') prepared by the autoplast formation. Although the cell bound lysozyme at 4°C, it resists to lysozyme digestion. A certain component contained in AS'formed an insobuble complex with lysozyme and inhibited the activity of lysozyme. The insoluble complex was mainly composed of protein and phosphate ester. The inhibitory activity was destroyed by heat, protease, or nuclease treatment. This suggests that the resistant factor is a non-peptidoglycan component of the cell wall.