Studies on Pyridinol Derivatives. III. Synthesis and Pharmacological Activity of 2H-Pyrido [3, 2-b]-1, 4-oxazin-3-one Derivatives. (2)

Abstract

Twenty five kinds of derivatives of 4-(3-dialkylamino-2-hydroxypropyl)-2H-pyrido-[3, 2-b]-1, 4-oxazin-3-one (9a-13e) were synthesized by three different methods, and obtained as hydrochloride. The following results were obtained from the preliminary investigation on the local anesthetic and the analgesic activities (mouse writhing test) of these synthesized compounds. Almost all of the compounds were inferior to cocaine or lidocaine on the local anesthetic action ; these were approximately equivalent to or slightly weaker than pyrabital.