Studies on the Constituents of Gynostemma pentaphyllum MAKINO. I. Structures of Gypenoside I-XIV

Abstract

New saponins, named gypenosides I (1), II (2), V (5), VI (6), VII (7), IX (9), X (10), XI (11), XIII (13), XIV (14), besides the known ginsenosides-Rb₁ (3), -Rb₃ (4), -Rd (8) and -F₂ (12), were isolated from Gynostemma pentaphyllum MAKINO. On enzymatic hydrolysis, all saponins yielded 20-O-β-D-glucopyranoside of 20 (S)-protopanaxadiol (compound K) as a prosapogenin. The configuration of the sugar linkages in each saponin was established on the basis of chemical and spectroscopic evidence.