トリテルペノイドサポゲニンを用いる液・固クロマトグラフィーにおける強成分溶媒の相対強度の図式化

抄録

To optimize a solvent system systematically for liquid-solid chromatography separation, the strength indices of stronger solvents such as diethyl ether (B₁), ethyl acetate (B₂), acetone (B₃), tetrahydrofuran (B₄), dioxan (B₅) and 2-propanol (AB) were determined on the basis of a linear relationship between the logarithm of the capacity ratios and the logarithm of the solvent composition in binary systems containing n-hexane (O) as a diluent. A new procedure for the graphic schematization of the relative strength and equi-eluotropic composition of stronger solvents is elaborated. The experimental results obtained with triterpenoid sapogenins were compared with the Snyder's solvent strength parameter and the Neher's calculation for predicting the equi-eluotropic solvent composition and the differences among three strength parameters are discussed.