Studies on Benzhydryl Derivatives. III. Synthesis and the Effect on Tumor Cells in Culture of Diphenylacetylamino Acids

Abstract

Diphenylacetyl derivatives of glycine (1), L-phenylalanine (2), DL-alanine (3), DL-serine (4), DL-valine (5), DL-leucine (6), L-aspartic acid (7), and L-glutamic acid (8) were synthesized and their effects on tumor cell were investigated using Sarcoma 180, HeLa, and KB cells. Compounds 2, 5, and 6 showed weak growth inhibition and damage of the tumor cells in culture.