β-受容体遮断作用を有する8-アシルアミノ-3,4-ジヒドロカルボスチリル誘導体の合成

抄録

Twenty one kinds of 8-acylamino-5-(2-hydroxy-3-substituted aminopropoxy)-3, 4-dihydrocarbostyril derivatives were synthesized and their antagonistic activities on isoproterenol were examined. Several compounds having 3, 4-dimethoxyphenethyl or 4-carbamoylphenoxyethyl moiety in 3-substituted amino group were found to have less antagonistic activity on isoproterenol than those with tert-butyl or isopropyl moiety in 3-substituted amino group, but showed relative higher selectivity for β₁-adrenoreceptors in the anesthetized dog.