Reaction of 3-Nitro-2, 6-dimethylpyridine N-Oxide with Potassium Cyanide. Formation of a Pyrido [3, 4-d] pyrimidine Derivative

Abstract

Reaction of 3-nitro-2, 6-dimethylpyridine (1) with potassium cyanide in methanol gave 3-methoxy-6-methylpyridine-2-carbonitrile 1-oxide (2), 5, 7-dimethyl-3-iminoisoxazolo [3, 4-c]-pyridine dimer (3) and 6, 8-dimethyl-4-oxo-3H-pyrido [3, 4-d] pyrimidine 7-oxide (4). The origin of the carbon atom of the pyrimidine derivative (4) was proved to be the carbon eliminated from 2-methyl group when 2 was produced from 1.