Antibacterial Activities of Amidinohydrazones. VII. Quantitative Relationships between Structure and Antibacterial Activities for Amidinohydrazones

Abstract

Quantitative relationships between structure and antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Trichophyton interdigitale were presented for 52 derivatives of N-alkyl-and N-arylamidinohydrazones of benzaldehydes, alkylphenylketones, benzophenones, biphenylcarboxaldehydes, acetylbiphenyls, acetylnaphtalenes, fluorenecarboxaldehydes, acetylfluorenes, anthracenecarboxaldehydes and acetylphenanthrenes. Satisfactory equations involving benzophenone derivatives were obtained for T. interdigitale but not for the bacteria.