A series of 5-(3-aryloxypropyl)-1-cyclohexyltetrazoles was synthesized and tested for inhibitory activity towards collagen- and adenosinediphosphate-induced aggregation of rabbit blood platelet in vitro. These compounds were prepared by the reaction of 1-cyclohexyl-5-(3-iodopropyl)-tetrazole with phenols in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl) propoxy]-1, 3-dihydro-1-ethyl-2H-benzimidazol-2-one (IVd) was found to have potent inhibitory activity. The structure-activity relationships are discussed.
