4位複素環を有する2,6-Di-tert-butylphenolsの合成と抗炎症作用に関する研究(第4報)4-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-oxo-4-imidazolinesの光酸素酸化および塩基触媒酸素酸化反応

抄録

Photo-oxygenation of 4-(3, 5-di-tert-butyl-4-hydroxyphenyl)-5-methyl-2-oxo-4-imidazoline (1b) gave 2, 6-di-tert-butyl-p-benzoquinone (2), N-acetyl-N'-(3, 5-di-tert-butyl-4-hydroxybenzoyl) urea (3) and 4-(3, 5-di-tert-butyl-4-oxo-2, 5-cyclohexadien-1-ylidene)-5-methoxy-5-methyl-2-oxo-imidazoline (4b), and 4b was the main product. Base-catalyzed oxygenation of 1b and related derivatives was carried out. Base-catalyzed oxygenation of 1b also gave 2, N-(3, 5-di-tert-butyl-4-hydroxybenzoyl) urea (5) and 4b. The mechanism of the reaction between 1b and oxygen giving compounds 2, 3, 4b and 5 was proposed.