10-Aryl-3,3-dimethyl-2,3,4,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]benzothiazepin-1-oneの合成

抄録

3-Arylmethylene-5, 5-dimethyltetramic acids (5a-i) were synthesized from 5, 5-dimethyltetramic acid (3) and aromatic aldehydes by an acid catalyzed aldol condensation. 10-Aryl-3, 3-dimethyl-2, 3, 4, 10-tetrahydro-1H-pyrrolo [3, 4-c] [1, 5] benzothiazepin-1-ones (9a-g) were prepared by Michael reaction between 2-aminobenzenethiol and 3-arylmethylene-5, 5-dimethyltetramic acids in good yield.