生薬の基源・修治・品質に関する研究 (第5報)

漢薬・朮の実験的胃潰瘍に対する予防効果の薬理学的評価その5白朮の抗ストレス潰瘍作用について

抄録

The aim of this study was to evaluate the effect of 50% methanolic extract of “Bai-Zhu” originating from Atractylodes ovata (AO) on the levels of 11-OHCS and that of gastrin in the plasma, gastric mucosal blood flow in rats with water-immersion stress and on the development of acute gastric mucosal lesions after a short period of waterimmersion restraint stress.
In rats administered AO orally, neither effects on the levels of 11-OHCS and gastrin in the plasma nor a change in gastric mucosal blood flow were observed, while in rats with water-immersion stress, AO prevented an increase in levels of 11-OHCS and gastrin, a decrease in gastric mucosal blood flow and the development of gastric mucosal lesions.
These findings indicate that AO exhibited the anti-ulcerogenic activity against stressulcer in preventing abnormal change in plasma levels of steroidal hormones and in remeding insufficient state of circulatory system caused by stress.