Abstract
In the previous paper, the anti-ulcer effect of an extract of Panacis Japonici Rhizoma, saponin fractions and chikusetsusaponin III was reported. In the present experiment, further examination was made on the mode of the anti-ulcer effect of chikusetsusaponin III, in several experimentally induced ulcers, and revealed that the anti-ulcer action of chikusetsusaponin III does not ascribe to an inhibition of gastric acid secretion. It was further concluded that chikusetsusaponin III may directly activate gastric membrane-protective factors, or that the anti-ulcer action may be related to the activation of natural body protection mechanisms through gastric mucosal irritating effects of the saponin in general.
