YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on Antiallergy Agent. II. Synthesis of 3-Benzoylacrylic Acids and the Related Compounds
KOHJI OZEKI, YASUHIRO ISHIZUKA, MASAHIRO SAWADA, HIROSHI SHIMAMURA, TERU ICHIKAWA, MAKOTO SATO, HIDEYA YAGINUMA
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Keywords: antiallergy agent, 3-benzoylacrylic acid, 3-benzoyl-2-hydroxypropionic acid, 3-benzoylpropionic acid
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1987 Volume 107 Issue 4 Pages 268-273

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Abstract
A series of 3-benzoylacrylic acids and the related propionic acids were prepared and evaluated for antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay. Several analogues of the 3-(4-substituted benzoyl) acrylic acids exhibited significant activity by oral administration, while none of the corresponding propionic acids were active. Structure-activity relationships were discussed.
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