抄録
The enhancing effect of lecithin (PC) on the percutaneous absorption of drugs in gelointment was investigated. Four hours after a topical application of indomethacin (IM) plus PC-gel-ointment, IM was absorbed through the intact rat back skin and moved into blood, but PC could not be found in the plasma. PC had no effect on the percutaneous absorption of IM through the stripped skin. The pretreatment with the base of gel-ointment containing only PC increased the percutaneous absorption of IM applied as gelointment 4h later. PC inhibited the peroxidation of skin lipids, but did not affect the release of SH group from skin protein. The percutaneous absorption of piroxicam (PX) and diclofenac (DF) was also enhanced by PC. It is suggested from these results that PC has a high affinity with epidermic tissue, changes the fluidity of tissue by hydration of stratum corneum, and enhances the percutaneous absorption of drugs.
