抄録
Hot water extracts of green tea showed a prolonged hypotensive effect in anesthetized rabbits. The major active principle was purified by chromatography on Polyamide C-200 and Sephadex LH-20, and identified as (-)-gallocatechin gallate ((-)-GCG). (-)-GCG at a dose of 0.1 mg/kg (i.v.) effectively reduced blood pressure in anesthetized rabbits and at 0.5 mg/kg lowered it by 20-40 mmHg for an extended period of time. This compound seems to be an artifact by epimerization of (-)-epigallocatechin gallate during heating extraction.
