1988 Volume 108 Issue 12 Pages 1196-1202
The mesenteric membrane permeability between the blood and peritoneal cavity was studied pharmacokinetically by using rat for two drugs; salicylamide (SAM) and salicylic acid (SA).
The intraperitoneal cavity was perfused continuously and SAM and SA were given by i. v. administration and from the perfusate.
But, benzoic acid (BA) was given only by i. v. administration.
The drug concentration in the blood and intraperitoneal perfusate were determined and analyzed pharmacokinetically.
The transport rate constants from the blood and intraperitoneal cavity of SAM were 20.8±1.2-10-3 and 40.3±2.2-10-3min-1, respectively. While those of SA were 0.97±0.33-10-3 and 6.6± 1.7-10-3 min-1, respectively.
The ratio of cumulative amount transported to the intraperitoneal cavity after i. v. administration to the dose administered was estimated by the area under the blood concentration-time curve. The values for SAM, SA and BA were 50.4, 6.8 and 5.6%, respectively.
