In order to develop a new tumor-detecting agent with D-amino acid as a parent compound, the preparation of 125I labeled D- and L-iodophenylglycines and their distribution in Ehrlich solid tumor-bearing mice were investigated. Each labeled compound was synthesized via the corresponding diazonium compound. The distribution pattern of the D-form was similar to that of the L-form. Although the tumor uptake of D-form, as well as L-form, at 60 min after the injection was higher than other organs except kidney, stomach, duodenum and thyroid, its uptake ratio was insufficient for use as a tumor-imaging agent.
