Quinoxaline誘導体に関する研究(第23報) : 2-Chloroquinoxalineと各種Nucleophileとの反応

飯島 千穂子; 林 英作

doi:10.1248/yakushi1947.108.5_437

YAKUGAKU ZASSHI

Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903

Quinoxalines. XXIII. : Reaction of 2-Chloroquinoxaline with Nucleophiles

CHIHOKO IIJIMA, EISAKU HAYASHI

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Keywords: 2-chloroquinoxaline, nucleophile, substitution, potassium cyanide, silver nitrite, potassium thiocyanate, 2-nitroquinoxaline

JOURNAL FREE ACCESS

1988 Volume 108 Issue 5 Pages 437-442

DOI https://doi.org/10.1248/yakushi1947.108.5_437

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Abstract

2-Chloroquinoxaline (I) reacted with NaI, sodium benzenesulfinate, sodium p-toluenesulfinate or KSCN to afford 2-iodoquinoxaline (V), 2-phenylsulfonylquinoxaline (IX), 2-(4-methylphenyl)sulfonylquinoxaline (X) or 2-quinoxalinyl thiocyanate (XVII) in good yield, respectively. Cyano and nitro groups were interduced into 2-position of quinoxaline in low yield by using of KCN and AgNO₂.

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