Abstract
Reaction of 2-chloroquinoxaline (I) and C-nucleophiles (benzyl cyanide (IIa), acetonitrile (IIa), diethyl malonate (IIc), ethyl cyanoacetate (IId), malonodinitrile (IIe), nitromethane (IIf), phenylacetylene (IIg)) was carried out in hexamethylphosphoramide in the presence of potassium hydroxide. IIa, c-e afforded α-phenyl-2-quinoxalineacetonitrile (IIIa), diethyl 2-quinoxalinemalonate (IIIc), ethyl α-cyano-2-quinoxalineacetate (IIId) and 2-quinoxalinemalonodinitrile (IIIe) in fairly good yield, respectively.
