1989 Volume 109 Issue 12 Pages 957-961
Synthesis and oral activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)-acetamido]-3-(1, 2, 3-triazol-1-yl) methyl-3-cephem-4-carboxylic acid and its related compounds were described. 3-(1, 2, 3-Triazol-1-yl) methylcephalosporins have been prepared by the direct cycloaddition of acetylene to 3-azidomethylcephalosporins, which were obtained by nucleophilic substitution of 3-chloromethylcephalosporins with sodium azide in N, N-dimethylformamide. The cephalosporins (8a-c) had potent and wide antibacterial spectra against gram positive and gram negative bacteria which were comparable to those of cefixime or cefteram. Urinary recovery of 9a and 9b, pivaloyloxymethyl esters of 8a and 8b, were 9.2% and 3.5%, respectively, through oral administration in mice, exhibiting lower rate than that of cefteram pivoxyl (28%).
