エテンザミドの家兎血漿中からの飽和過程を伴う消失に関する同時あてはめの適用
1989 年 109 巻 7 号 p. 499-504
詳細
1989 年 109 巻 7 号 p. 499-504
Intravenous and oral administrations of ethenzamide (EZ) were carried out in the rabbit, and elimination process pharmacokinetically discussed. When the drug dose increased, plasma clearance and extent of bioavailability were reduced and plasma peak times delayed after oral dosing of EZ. Michaelis-Menten type elimination parameters were estimated from the plasma concentration-time profiles after intravenous dosing of EZ. The first-order absorption rate constant (ka), hepatic available fraction (FH) and approximate elimination rate constant (K) for hepatic first-pass metabolism of EZ were estimated using computer multi-lines fitting technique by iterative nonlinear least squares regression program, MULTI (RUNGE).
