1990 年 110 巻 2 号 p. 144-154
The selective toxicity was often shown by experiments with in vitro screening test in human cancer cell (JTC-26) and human normal embroyonic cell (HE-1) on the crude extract of crude drugs. The active fractions with selective toxicity were obtained by column chromatography. However, the selective toxicity disappeared in the simple constituent in which the activity remained. The selective toxicity of crude drugs was presumed to appeare with the complex constituents.