YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
The Study on Chinese Herbal Medicinal Prescription with Enzyme Inhibitory Activity. III. The Study of Mao-to with Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase
Tamotsu NIKAIDO, Taichi OHMOTO, Takashi KUGE, Akiko YANAGISAWA, Kiyomi TEINOZAWA, Hajime TAKEDA, Hiroki TSUKAMOTO
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Keywords: Chinese herbal medicine, mao-to, cAMP phosphodiesterase, inhibition, Ephedra herb, Apricot kennel, mitigatory component, ephedrine, Cinnamon bark, Glycyrrhiza
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1990 Volume 110 Issue 7 Pages 504-508

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Abstract
Mao-to, a Chinese herbal medicinal prescription was studied for the inhibitory activity of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase. The inhibitory activity for this enzyme depended mainly on Ephedra herb and Glycyrrhiza in this prescription. Apricot kennel acted as a mitigatory component for Ephedra herb in cAMP phosphodiesterase inhibitory test. In ephedrine and the related compounds the inhibitory activity of cAMP phosphodiesterase was not shown.
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