生薬・ウワウルシの薬理学的研究(第5報)Dexamethazone軟膏の抗アレルギー及び抗炎症効果に及ぼすウワウルシ水抽出エキスの影響

抄録

Effects of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) SPRENG. (Bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethazone ointment were investigated. One or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. UW-ext augmented the inhibitory effect of dexamethazone ointment (0.005 or 0.025%) on these allergic and inflammatory models, but not the side effect of it. These results suggest that Bearberry leaf increases the inhibitory effect of dexamethazone on the allergic and inflammatory models.