核酸ピリミジン塩基の化学修飾と修飾塩基による変異誘起.過マンガン酸酸化と亜硫酸付加修飾を中心に
1993 年 113 巻 1 号 p. 19-31
詳細
1993 年 113 巻 1 号 p. 19-31
Methods for modifying nucleic acids and their components with permanganate and with bisulfite are reviewed, with emphasis on work developed by the author's group of investigators. N (4) Aminocytidine, a nucleoside analog obtainable on bisulfite-hydrazine modification of cytidine, is a potent mutagen, and the mechanism of its action in the mutagenesis is discussed.
