YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Pharmacological Studies on Human Urinary Kallidinogenase (SK-827) : Effects on Cerebral Metabolism
Hiroshi NAGANO, Tsunemasa SUZUKI, Tetsushi TOMOGURI, Motohide HAYASHI, Kaito TSURUMI
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Keywords: human urinary kallidinogenase (SK-827), cerebral metabolism, cerebral blood flow, infarcted rabbit
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1993 Volume 113 Issue 11 Pages 825-828

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Abstract
We investigated the effects of human urinary kallidinogenase (SK-827) on cerebral metabolism in normal and infarcted rabbits. SK-827 did not influence cerebral glucose and oxygen uptake in normal rabbits. In infarcted rabbits, cerebral glucose and oxygen uptake significantly decreased. SK-827 tended to inhibit the decrease of cerebral blood flow, and significantly inhibited the decrease of cerebral glucose and oxygen uptake in infarcted rabbits. Thus, SK-827 improved cerebral glucose metabolism in infarcted rabbits.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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