経口セフェム系抗生物質の消化管吸収に及ぼすペプチド経腸栄養剤エンテルード[○!R]併用の影響
1994 年 114 巻 4 号 p. 233-240
詳細
1994 年 114 巻 4 号 p. 233-240
The effect of simultaneous administration of Enterued[○!R], an elemental diet, which is composed of oligopeptides (egg white hydrolyzate), on the orally active cefems was investigated. Ceftibuten (CETB) administered together with Enterued[○!R] to man was excreted slower in the urine. AUC from the plasma concentrations of CETB after the oral administration with Enterued[○!R] was markedly decreased compared to that without Enterued[○!R] in rat. In contrast, neither urinary excretion of cephalexin (CEX) in man nor the AUC from the plasma profile of CEX in rat was changed by Enterued[○!R]. Furthermore, the disappearance, tissue accumulation, net absorption of CETB from the rat jejunal loop were significantly inhibited by Enterued[○!R]. However, the net absorption of CEX has no alternation in the presence of Enterued[○!R], although the apparent disappearance decreased on the basis of the diminishment of tissue accumulation. Additionally, Hepan ED[○!R], which is an elementary diet composed of amino acids, and the mineral solution containing neither peptides nor vitamins have also exhibited the decreasing effect on the CETB absorption behaviour. These results suggested that the inhibitory effects of Enterued[○!R] on the absorption of these antibiotics were not due to the inhibition of peptide-transport systems.
