漢方方剤の抗発癌プロモーター作用(第2報)小青龍湯によるマウス皮膚及び肺発癌プロモーター抑制効果
1994 年 114 巻 4 号 p. 248-256
詳細
1994 年 114 巻 4 号 p. 248-256
To search for possible anti-tumor promoters, we carried out a primary screening of fourteen kampo prescriptions utilizing their possible inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). In these prescriptions, shouseiryu-to exhibited the most significant inhibitory effect on the EBV-EA activation. Furtheremore, two-stage carcinogenesis of mouse skin tumors induced by 7, 12-dimethylbenz [α] anthracene (DMBA) and TPA, and mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide (4NQO) and glycerol were strongly inhibited by shouseiryu-to.
