漢方薬の作用原理から創薬設計への分子病態薬理学的研究

抄録

In this study we carried out the pharmacological elucidation of the principle of drug action in the Japanese traditional Sino-medicine system, which could have contributed to the modern pharmacology and therapeutics through the discovery of a novel drug design and a new mechanism of drug action. The aim of this study was to focus on the elucidation of the supporting moiety in the drug design for the drug having affinity for a patho-receptor using a quite unique strategy and a new approach based on the natural products, Japanese traditional Sino-medicines relating to disease state, because of enormous clinical experiences with a long history. The characteristics of the pharmacological effects of Japanese traditional Sino-medicines were experimentally demonstrated by the following three key compartments, 1) the combined effect of drugs, 2) the selective activity of drugs to the disease state, 3) the possibility of individual symptomatological patterns (sho) evaluated by autonomic and immunopharmacological components. The success of the investigation on the principle of drug action of Japanese traditional Sino-medicines induced not only to obtain many novel compounds and unknown new mechanisms of drug action, but also to find a new salivary peptide for anti-hyperglycemics and a fresh mechanism of ACh receptor desensitization in neuromuscular synapse in the modern pharmacology. The results have brought the interchangeability of Japanese traditional Sino-medicine system to modern medicinal sciences, as described in the following contents, I. On the elucidation of a principle of drug action in the Japanese traditional Sino-medicine system. II. On the developmental frontier of drug design based on Japanese traditional Sino-medicines. III. On the interchangeability between the Japanese traditional Sino-medicine system and the modern medicinal sciences.